This paper brings together two promising intellectual trends in development: Doing Development Differently (DDD), and whole-system reform. In addition, it provides a framework for evaluating system reforms, as rigorously as possible. This paper adapts some concepts from the paper “A Practical Approach to In-Country Systems Research” written for the Research on Improving Systems of Education (RISE) Programme. This version turns more toward the Doing Development Differently movement rather than education systems reform. The original paper was presented at the first RISE conference in Washington, DC, June 18–19, 2015.