The USAID/Uganda School Health and Reading Program is a large scale, systemic reform effort to increase reading and provide health information in primary schools. This is one of the first Early Grade Reading Studies in Africa to combine rigorous research methods with a large scale reform working through Ministry of Education Systems. This briefer highlights the findings from a Randomized Control Trial/Early Grade Reading Assessment for the first 4 languages (of 12 total program local languages and English) to start the program in Primary 1 in 2013: Ateso, Leblango, Luganda, and Runyunkore-Rukiga. Findings: At the end of Primary 4, learners are between 1.5 and 6 times more likely to be reading 40 or more words per minute in the local language in program schools compared to control schools (all statistically significant differences with effect sizes ranging from 0.39 to 0.75). Program learners were also significantly more likely to be reading 60 or more words per minute in English in 3 of the 4 languages.