The Uzbekistan Education for Excellence Program (the Program), funded by the United States Agency for International Development (USAID), designed the Information and Communication Technology (ICT) and English as a Foreign Language (EFL) Teacher Guide Uptake Study (TGUS) to determine teachers’ uptake of new teacher guides (TGs), teachers’ application of student-centered strategies, and the appropriateness of the design of the TGs themselves. The Program used the results and ensuing recommendations to inform the development and finalization of its teacher professional development efforts and TGs, respectively.