An integral part of a decentralized education system hierarchy is the “middle tier” comprising subnational actors in charge of education delivery at the regional, provincial, state, district, municipality, city, or circuit and cluster levels. The general roles and responsibilities of the middle tier are described in research on district leadership in OECD countries. Their responsibilities range from planning, monitoring, and implementing reforms at the subnational and school levels, to ensuring school-based accountability through data and evidence, to innovating, supporting, and monitoring improvements in teaching and learning in schools through instructional leadership and fostering professional learning communities at the district and school levels. While rigorous academic evidence may be lacking on the ability of middle managers to bring about improvements in foundational literacy and learning outcomes at scale in LMICs, we have theoretical and programmatic evidence on (1) their role in instructional leadership, (2) the importance of building their capacity to drive teaching and learning, and (3) the importance of trust and support within the education system that fosters learning at scale. Thumbnail Credit: Pakistan Reading Program/IRC